Parallel Inducible Cell Based Kinase Screen


A parallel inducible cell-based kinase screen (PICKS) includes a plurality ofcells that express a kinase gene under the control of an inducer and a reporter gene, wherein the cells are derived from a single cell line, and wherein the reporter gene generates a signal in response to catalytic activity or inhibition of the expressed kinases. […]

Enzyme Inhibitors and Methods Therefor


An enzyme is inhibited by presenting the enzyme with a boron containing structure having a tetrahedral boron atom covalently bound to four ligands. Particularly preferred enzymes include prostaglandin endoperoxide synthase (COX-1 and COX-2), and particularly preferred structures include a ligand that confers at least 80-fold selectivity of COX-2 inhibition over COX-1 inhibition. Consequently, further methods […]

Monocyclic L-Nucleosides, Analogs, and Uses Thereof


Novel monocyclic L-Nucleoside compounds have the general formula __. Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel compounds show immunomodulatory activity, and are expected to be useful in modulating the cytokine […]

Microarray Detector and Methods


A detector for optical analysis of a biochip determines the focal position of a plurality of analytes on the biochip using one or more registration markers on the biochip, wherein the analytes and the registration marker are illuminated by different light sources. Therefore, contemplated configurations will significantly reduce overall focusing time and automate proper positioning […]

Stent Covered by a Layer Having a Layer Opening


A drug eluting stent has a frame with at least one frame opening, and the frame is covered with an outer continuous layer and/or an inner continuous layer. The outer and/or inner layers further include a layer opening that at least partially overlaps with the frame opening to form a continuous opening having a size […]

Module for Automated Matrix Removal


An automated matrix removal module is configurable to automatically withdraw a portion of sample containing an interferent. The module is further configurable to mix the portion of sample with a precipitating reagent selected to react with the interferent to fonn a precipitant and then filter mixture of sample and precipitant reagent through a filter. Finally, […]

Cervical Collar with End-Supported Chin Strap


The cervical collar has three principal pieces: a back panel, a main collar body, and a chin piece. The chin piece is permanently attached to the main collar body and is only attached at its ends to the main collar body so that the center portion of the chin piece can adjust to chin configuration. […]

Improved Distillation Systems


A differential vapor pressure (DVP) cell (150) is disposed in a divided wall column (100) that receives a feed comprising a first (102A), second (102B), and third (102C) component. A separation section (120) on the feed side of the divided wall column separates the feed in a vapor comprising the first and second component, and […]

Lanthanide Batteries


A battery (100) comprises an electrolyte in which a lanthanide and zinc form a redox pair. Preferred electorlytes are acid electrolytes, and most preferably comprise methane sulfonic acid, and it is further contemplated that suitable electrolytes may include at least two lanthanides. Contemplated lanthanides include cerium, praseodymium, neodymium, terbium, and dysprosium and further contemplate lanthanides […]