Procedures for Obtaining Ribo-C-Nucleosides

US05907036

Novel procedures for obtaining ribo-C-nucleosides, including especially 2-ß-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-ß-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the 1′ position of a ribose, directly or indirectly converting the cyano group to HN=C–OR1 or thicarboxylamide wherein R1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.